Type IV Secretion in Gram-Negative and Gram-Positive Bacteria

Biological diversity of prokaryotic type IV secretion systems.- Evolution of type IV secretion systems and their substrates.- Structural and molecular biology of type IV secretion systems.- Relaxosome formation and transfer of broad-host range plasmids Gram-negative bacteria.- Mechanisms of conjugative transfer by Gram-positive broad-host range plasmids.- Social behavior and decision making in bacterial conjugation.- Structure and chemical biology approaches to understand type IV secretion system function and inhibition.- Type IV secretion systems: A pivotal tool to establish intracellular lifestyle by pathogens.- Subversion of host target cells by the Legionella type IV secretion system.- Role of multiple type IV secretion systems in Bartonella infections.- Requirements for T4SS effector protein translocation and function by the Coxiella Dot/Icm system.- Composition and function of the Helicobacter pylori cag type IV secretion system.- Secretion of chromosomal DNA by the gonococcal type IV secretion system.

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• Doenças e desvios
• Microbiologia e virologia médicas
• Imunologia
• Cirurgia gastrointestinal e colorectal

Gram-negative bacteria;Intracellular lifestyle;Legionella;Bartonella infections;Helicobacter pylori;Membrane-associated transporter complexes;Gram-positive bacteria;Eukaryotic cells;Interbacterial transfer;Antibiotic resistance;T4SS;infectious diseases