New Approaches to Drug Discovery
-15%
portes grátis
New Approaches to Drug Discovery
Jaroch, Stefan; Fuhrmann, Ulrike; Nielsch, Ulrich
Springer International Publishing AG
04/2018
341
Mole
Inglês
9783319804552
15 a 20 dias
5969
Descrição não disponível.
Preface.-
Part 1. Historical View.- Drug discovery in the past and today.Part 2. Target Discovery.- Emerging target families:
intractable targets. In vivo target validation especially for biological
targets. HR RNAi/High Content analysis.- Part 3. Lead generation and Optimization.- Sources for leads: natural products,
libraries. Screening: assays, readout, technology. Impact of structural
biology, fragment based screening/Virtual screening. Predictive in silico tools
of compound properties. High throughput synthesis. New compound classes:
Protein-Protein Interaction. Sources for biological leads/Screening of
biologicals.- Part 4. Test systems for
Efficacy and Safety.- In vitro
/ Cell based assays. Pharmacodynamic. Pharmacokinetic. Safety and toxicology. Impact
of biomarkers/personalized medicine. Simulating in vivo drug effects.
Part 1. Historical View.- Drug discovery in the past and today.Part 2. Target Discovery.- Emerging target families:
intractable targets. In vivo target validation especially for biological
targets. HR RNAi/High Content analysis.- Part 3. Lead generation and Optimization.- Sources for leads: natural products,
libraries. Screening: assays, readout, technology. Impact of structural
biology, fragment based screening/Virtual screening. Predictive in silico tools
of compound properties. High throughput synthesis. New compound classes:
Protein-Protein Interaction. Sources for biological leads/Screening of
biologicals.- Part 4. Test systems for
Efficacy and Safety.- In vitro
/ Cell based assays. Pharmacodynamic. Pharmacokinetic. Safety and toxicology. Impact
of biomarkers/personalized medicine. Simulating in vivo drug effects.
Este título pertence ao(s) assunto(s) indicados(s). Para ver outros títulos clique no assunto desejado.
Biologics;Drug characterization;Drug discovery;Drug optimization;Drug targets;Preclinical research;Metabolomics
Preface.-
Part 1. Historical View.- Drug discovery in the past and today.Part 2. Target Discovery.- Emerging target families:
intractable targets. In vivo target validation especially for biological
targets. HR RNAi/High Content analysis.- Part 3. Lead generation and Optimization.- Sources for leads: natural products,
libraries. Screening: assays, readout, technology. Impact of structural
biology, fragment based screening/Virtual screening. Predictive in silico tools
of compound properties. High throughput synthesis. New compound classes:
Protein-Protein Interaction. Sources for biological leads/Screening of
biologicals.- Part 4. Test systems for
Efficacy and Safety.- In vitro
/ Cell based assays. Pharmacodynamic. Pharmacokinetic. Safety and toxicology. Impact
of biomarkers/personalized medicine. Simulating in vivo drug effects.
Part 1. Historical View.- Drug discovery in the past and today.Part 2. Target Discovery.- Emerging target families:
intractable targets. In vivo target validation especially for biological
targets. HR RNAi/High Content analysis.- Part 3. Lead generation and Optimization.- Sources for leads: natural products,
libraries. Screening: assays, readout, technology. Impact of structural
biology, fragment based screening/Virtual screening. Predictive in silico tools
of compound properties. High throughput synthesis. New compound classes:
Protein-Protein Interaction. Sources for biological leads/Screening of
biologicals.- Part 4. Test systems for
Efficacy and Safety.- In vitro
/ Cell based assays. Pharmacodynamic. Pharmacokinetic. Safety and toxicology. Impact
of biomarkers/personalized medicine. Simulating in vivo drug effects.
Este título pertence ao(s) assunto(s) indicados(s). Para ver outros títulos clique no assunto desejado.
