Chromosomal Translocations and Genome Rearrangements in Cancer

Part I Introduction.- A short history of chromosome rearrangements and gene fusions in cancer.- Part II General.- Molecular genetics methods in discovery of chromosome structure.- Mechanism of recurrent chromosomal translocations.- Chromosome translocations, cancer initiation and clonal evolution.- Chromosomal fragile sites and cancer.- Copy number changes in carcinomas: applications.- Part III LEUKAEMIA/LYMPHOMA.- Chronic myeloid leukaemia.- Immunoglobulin and MYC rearrangements in multiple myeloma pathogenesis.- Genetic alterations in B cell lymphoma.- Chromosomal translocations and gene rearrangements in acute lymphoblastic leukaemia.- Cellular and molecular basis of MLL leukaemias: from transformation mechanisms to novel therapeutic strategies.- Acute promyelocytic leukaemia: from a specific translocation to cure by targeted therapies.- Chromosome Abnormalities in AML and their clinical importance.- PART IV SARCOMAS.- Fusion Oncogenes of Sarcomas.- Translocations in Ewing Sarcoma.- PART V EPITHELIAL TUMOURS.- RET and thyroid carcinomas.- Gene fusions in prostate cancer.- Chromosomal Translocations in Lung Cancer.- Colon & Ovarian translocations.- PART VI OTHER ASPECTS.- Pre-clinical modeling of chromosomal translocations and inversions.- Protein complex hierarchy & translocation gene products.- Aberrant transcriptional programming in blood cancers.- Index.

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• Pesquisa médica
• Biologia Celular (citologia)
• Oncologia
• Genética médica

Cancer genomes;Chromosomal abnormalities;Chromosomal translocations;Genome rearrangement;Somatic mutation, Oncogenes