Shiga toxins
-15%
portes grátis
Shiga toxins
A Review of Structure, Mechanism, and Detection
Brandon, David L.
Springer International Publishing AG
03/2017
118
Dura
Inglês
9783319505794
15 a 20 dias
Descrição não disponível.
1. Outbreaks of Shiga toxin-related poisoningAn overview of the numerous major outbreaks of Shiga toxin related poisonings that have occurred in the United States and Europe, including- the early outbreaks at McDonalds in 1982, the infamous Jack in the Box outbreak in 1993 - the European outbreak associated with fresh sprouts in 2013- 9 outbreaks associated with spinach or lettuce from the Salinas Valley of California's central coast. 2. Structure of Shiga toxins-- a complex structure and mechanism of action-- six subunits, five identical binding units and one catalytic unit that is responsible for the toxicity-- relationship between Shiga toxins and other AB5 toxins-- subtypes of Shiga toxins and new variants that have recently emerged. 3. Mechanism of action-- the phage biology that controls the production of the toxins-- translocation of toxin to sites of action-- toxin action at the cellular and molecular level. 4. Significant threats to human health-- impact of antibiotics and antibiotic resistance on STEC disease-- intoxication with more than one toxin-- sequellae of STEC-provoked disease. 5. Methods for detection of Shiga toxins-- classical animal bioassay-- immunoassay, including ELISA and solid and bead array systems-- cell-based methods-- indirect PCR-based methods-- instrumental methods, including mass spectrometry, for directly detecting these toxins. 6. Conclusions and a glimpse into the future-- a significant and growing threat to human health and food biosecurity-- translation of lab bench science into clinical treatments for STEC disease.
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1. Outbreaks of Shiga toxin-related poisoningAn overview of the numerous major outbreaks of Shiga toxin related poisonings that have occurred in the United States and Europe, including- the early outbreaks at McDonalds in 1982, the infamous Jack in the Box outbreak in 1993 - the European outbreak associated with fresh sprouts in 2013- 9 outbreaks associated with spinach or lettuce from the Salinas Valley of California's central coast. 2. Structure of Shiga toxins-- a complex structure and mechanism of action-- six subunits, five identical binding units and one catalytic unit that is responsible for the toxicity-- relationship between Shiga toxins and other AB5 toxins-- subtypes of Shiga toxins and new variants that have recently emerged. 3. Mechanism of action-- the phage biology that controls the production of the toxins-- translocation of toxin to sites of action-- toxin action at the cellular and molecular level. 4. Significant threats to human health-- impact of antibiotics and antibiotic resistance on STEC disease-- intoxication with more than one toxin-- sequellae of STEC-provoked disease. 5. Methods for detection of Shiga toxins-- classical animal bioassay-- immunoassay, including ELISA and solid and bead array systems-- cell-based methods-- indirect PCR-based methods-- instrumental methods, including mass spectrometry, for directly detecting these toxins. 6. Conclusions and a glimpse into the future-- a significant and growing threat to human health and food biosecurity-- translation of lab bench science into clinical treatments for STEC disease.
Este título pertence ao(s) assunto(s) indicados(s). Para ver outros títulos clique no assunto desejado.
